July 7 - 9, 2004, Novosibirsk, Russia

Budker Institute of Nuclear Physics,
Novosibirsk, Russia


Early in the 90s, Japanese scientists showed that boron neutron capture therapy (BNCT) allows treating brain glioblastoma multiforme and melanoma, that are resistant to other methods of treatment. Glioblastoma multiforme afflicts approximately one of 20,000 people every year. The disease is always fatal, usually within six months of onset. Surgery and conventional radiation therapies may prolong life for as much as a year but do not stop the spread of tumors throughout the brain. This event in the early 90s gave a good intensification in study boron neutron capture therapy. In 1994 BNCT irradiation was re-initiated in the US. Glioblastoma multiforme patients have been treated at Massachusetts Institute of Technology Research Reactor and Brookhaven Medical Research Reactor. In 1997, clinical trials began in Petten, the Netherlands, as a result of joint effort of the European Community. In June 1999 clinical trials began in Finland, in 2000 - in Czesh Republic, 2002 - Sweden and Italy, 2003 - Argentina, in the near future clinical testing in Australia and Korea will be started. All these studies are conducted at specially constructed or adapted nuclear reactors. Progress in BNCT at clinical trials at reactors and prospects of the technique led to intensive discussion of development and construction of neutron source based on compact and inexpensive accelerator available for every oncologic hospital. Now, works are carried out at accelerators available at the number of scientific centers, and pilot accelerator based source of epithermal neutrons is under construction at the Budker Institute of Nuclear Physics.

The International Symposium on Boron Neutron Capture Therapy was held in Novosibirsk, July 7-9, 2004. It was organized by the Budker Institute of Nuclear Physics, Novosibirsk, with support of the International Science and Technology Center.

The main objectives of the Symposium were to serve as a review of the progress in the development of accelerators for BNCT irradiation systems, as well as review clinical aspects. The program of Symposium included review lections, invited papers, contributed papers, round-table discussion, and ISTC seminar. The main topics of the papers were following: accelerator based neutron source; medical physics; treatment planning; clinical aspects. This meeting allowed to coordinate efforts of Russian investigating groups, some of which are supported by International Science and Technology Center.

S. Taskaev
Novosibirsk, July 21, 2004


Small accelerators for the next generation of BNCT irradiation systems
T. Kobayashi, K. Tanaka, G. Bengua, M. Hoshi, Y. Nakagawa

Accelerator based neutron source for neutron capture therapy
B. Bayanov, Yu. Belchenko, V. Belov, V. Davydenko, A. Donin, A. Dranichnikov, A. Ivanov, I. Kandaurov, G. Kraynov, A. Krivenko, A. Kudryavtsev, N. Kuksanov, R. Salimov, V. Savkin, V. Shirokov, I. Sorokin, S. Taskaev, M. Tiunov

Development and study of cw H- source for BNCT
Yu. Belchenko, A. Khilchenko, A. Kryuchkov, V. Savkin, I. Ivanov, I. Piunov

Coupling H- ions beam line for tandem accelerator
S. Konstantinov, A. Krjutchkov, A. Kudryavtsev, O. Myskin, I. Sorokin, M. Tiunov

Test experiments for ion beam injection at the prototype of electrostatic tandem accelerator
V. Davydenko, A. Ivanov, I. Kandaurov, O. Myskin, M. Tiunov

Status of high-current tandem accelerator for the neutron therapy facility
V. Dolgushin, G. Kraynov, E.Pokhlebenin, V. Shirokov, I. Sorokin

Source of the accelerating voltage in the high-voltage tandem accelerator for neutron capture therapy
M. Veis, N. Kuksanov, P. Nemytov, V. Prudnikov, R. Salimov. S. Fadeev

Stripping target for a 10 mA, 1 MeV negative-hydrogen ion beam
V. Davydenko, A. Krivenko

Optimization of lithium target for epithermal neutrons generation
B. Bayanov, V. Belov, V. Kindyuk, S. Taskaev

Temperature regime in neutron production target for BNCT
T. Vsevolozhskaya

Accelerator based epithermal neutron source for NCT
V. Kononov, O. Kononov, N. Soloviev, M. Bokhovko

Accelerator based neutron sources for medicine
V. Kononov, M. Bokhovko, O. Kononov

The high frequency compact generator of accelerating voltage on 500 kV, 10 kW
A. Babkin, P. Bykov, G. Krainov, G. Sil'vestrov, V. Shirokov, Yu. Tokarev

Dc tandem surface-plasma source of H- ions with current up to 100 mA
G. Dimov

Tape high power neutron producing target for NCT
V. Kononov, G. Smirnov, S. Taskaev

Recent methods of brain malignant tumor diagnostics and therapy
V. Kanygin

NCT at the MEPhI reactor
K. Zaitsev, A. Portnov, V. Sakharov, V. Troshin, V. Savkin, V. Kvasov, O. Mishcherina, V. Kulakov, V. Khokhlov, I. Sheino, V. Meshcherikova, V. Mitin, N. Kozlovskaya, I. Shikunova

Estimation of neutron kerma in biological tissue containing boron and gadolinium compounds for neutron capture therapy
I. Sheino, V. Khokhlov, V. Kulakov, K. Zaitsev

Fast reactor neutrons in the treatment of malignancies and perspectives of NCT and NCT enhanced fast neutron therapy in Obninsk, Russia
I. Gulidov, A. Sysoev, Yu. Mardynsky, S. Ulianenko, S. Kapchigashev, V. Kononov, B. Fursov