Proc. 9th International Symposium on Neutron Capture Therapy for Cancer, October 2-6, 2000, Osaka, Japan

INVITED LECTURE

October 3^rd 9:30～10:15 Conference Hall A (1003)

Chairman: Koji Ono, Kyoto University Research Reaction Institute, Japan

IL-1 THE STATUS OF BNCT IN RADIATION ONCOLOGY -PROBLEMS AND EXPECTATIONS-

Mitsuyuki Abe, Hyogo Medical Center for Adults, Japan

October 5^th 9:00～9:45 Conference Hall A (1003)

Chairman: Satoshi Ueda, National Maiduru Hospital, Japan

IL-2 BORON NEUTRON CAPTURE THERAPY FOR MALIGNANT MELANOMA –RETROSPECTIVE AND PERSPECTIVE OF CLINICAL TRIALS-

Masamitsu Ichihashi, Kobe University, Japan

October 6^th 9:00～9:45 Conference Hall A (1003)

Chairman: Mitsunori Kirihata, Osaka Prefecture University, Japan

IL-3 BORON NEUTRON CAPTURE THERAPY: WHAT IS NEXT?

Detlef Gabel, University of Bremen, Germany

* Hatanaka Memorial Lecture

PLENARY LECTURE

October 3^rd 10:45～12:00 Conference Hall A (1003)

Chairman: Hiroshi Utsumi, Kyoto University Research Reaction Institute, Japan

PL-1 THE NEW FISSION CONVERTER BASED EPITHERMAL NEUTRON IRRADIATION FACILITY AT MIT

Otto K. Harling, et al; MIT, U.S.A.

PL-2 DOSE AND VOLUME SPECIFICATION FOR REPORTING NCT : AN ICRU-IAEA INITIATIVE

Andre C. Wambersie, et al; ICRU, U.S.A.

PL-3 BNCT OF BRAIN TUMORS: THE CHALLENGES FOR THE NEXT DECADE

Rolf F. Barth, et al; The Ohio State University, U.S.A.

October 5^th 9:45～10:10 Conference Hall A (1003)

Chairman: Satoshi Ueda, National Maiduru Hospital, Japan

PL-4 RETROSPECTIVE REVIEW OF THE CLINICAL BNCT TRIAL AT BROOKHAVEN NATIONAL LABORATORY

Aidnag Zaid Diaz, et al; Brookhaven National Laboratory, U.S.A.

October 6^th 9:45～10:10 Conference Hall A (1003)

Chairman: Mitsunori Kirihata, Osaka Prefecture University, Japan

PL-5 PRELIMINARY CLINICAL RESULTS FROM THE EORTC 11961 TRIAL AT THE PETTEN IRRADIATION FACILITY

Wolfgang Sauerwein, et al; EORTC BNCT Study Group, German

ORAL PRESENTATION

Biodistribution of Boron-10

October 3^rd 13:30～15:10 Conference Hall A (1003)

Chairmen: Jeffrey Albert Coderre, Brookhaven National Laboratory, U.S.A.

Yuko Kinashi, Kyoto University, Japan

OR-1 LONG-TERM BPA INFUSIONS: EVALUATION IN THE RAT BRAIN TUMOR AND RAT SPINAL CORD MODELS

Jeffrey Albert Coderre, et al; Brookhaven National Laboratory, U.S.A.

OR-2 ¹⁰Ｂ UPTAKE BY CELLS FOR BORON NEUTRON CAPTURE SYNOVECTOMY

Emanuela Binello, et al; MIT, U.S.A.

OR-3 HIGH LATERAL RESOLUTION, QUANTITATIVE SIMS ANALYSIS OF BORON-10 IN RAT BRAIN TISSUE

A. Caroline Oyedepo, et al; University of Bristol, U.K.

OR-4 BORON UPTAKE BY ERYTHROCYTES FOLLOWING BORONOPHENYLALANINE-FRUCTOSE INFUSION IN HUMANS

William Stead Kiger, Ⅲ, et al; MIT, U.S.A.

OR-5 BORON BIODISTRIBUTION AFTER BORONOPHENYLALANINE-FRUCTOSE (BPA-F) INFUSION

Merja E. Kallio, et al; University of Helsinki, Finland

Clinical Results

October 3^rd 15:40～17:20 Conference Hall A (1003)

Chairman: Yoshifumi Oda, Kobe City Hospital, Japan

Katalin Hideghйty, University of Essen, Germany

OR-6 A PHASE-Ⅰ CLINICAL TRIAL FOR CRANIAL BNCT AT HARVARD-MIT

Paul Martin Busse, et al; Harvard Medical School,　U.S.A.

OR-7 INTRAOPERATIVE BORON NETURON CAPTURE THERAPY FOR MALIGNANT GLIOMAS: FIRST CLINICAL RESULTS OF TSUKUBA PHASE Ⅰ/Ⅱ TRIAL USING JAERI MIXED THERMAL -EPITHERMAL BEAM

Akira Matsumura et al; University of Tsukuba, Japan

OR-8 FIRST CLINICAL RESULTS ON THE FINNISH STUDY ON BPA-MEDIATED BNCT IN GLIOBLASTOMA

Heikki Joensuu, et al; Helsinki University Hospital, Finland

OR-9 BORON NEUTRON CAPTURE THERAPY IN JAPAN -COMBINATION OF SURGICAL PROCEDURE AND EPITHERMAL NEUTRON-

Yoshinobu Nakagawa, et al; National Kagawa Children’s Hospital, Japan

OR-10 NEW EORTC CLINICAL TRIALS FOR BNCT

Katalin Hideghйty, et al; EORTC BNCT Group, Germany

Reactor Neutron Source

October 3^rd 13:30～15:10 Conference Hall B (1001)

Chairman : Iiro Auterinen, VTT Chemical Technology, Finland

Yoshinori Sakurai, Kyoto University, Japan

OR-11 EPITHERMAL NEUTRON BEAM FOR BNCT RESEARCH AT THE WASHINGTON STATE UNIVERSITY TRIGA RESEARCH REACTOR

David W. Nigg, et al; Idaho National Engineering and Environmental Laboratory, U.S.A.

OR-12 THE SWEDISH FACILITY FOR BORON NEUTRON CAPTURE THERAPY

Kurt Skцld, et al; Studsvik Medical AB, Sweden

OR-13 VALIDATION OF THE EPITHERMAL NEUTRON BEAM AT LVR-15

Milan Marek, et al; Nuclear Research Institute Rez, Czech Republic

OR-14 IMPROVING THE PERFORMANCE OF THE FiR 1 BNCT FACILITY

Iiro Auterinen, et al; VTT Chemical Technology, Finland

OR-15 UNIVERSITY OF CALIFORNIA DAVIS COMPREHENSIVE NEUTRON CAPTURE THERAPY PROGRAM

Susan Ann Autry-Conwell, et al; University of California Davis, U.S.A.

Accelerator Neutron Source

October 3^rd 15:40～17:20 Conference Hall B (1001)

Chairman : William T. Chu, Berkeley Lab, U.S.A.

Masaharu Hoshi, Hiroshima University, Japan

OR-16 POST-PROCESSING OF MONTE CARLO SIMULATIONS FOR RAPID BNCT SOURCE OPTIMIZATION STUDIES

Darren L. Bleuel, et al; Lawrence Berkeley Natl. Lab., U.S.A.

OR-17 THE INVESTIGATION OF THE UNDER-SURGERY IRRADIATION OF NCT USING NEAR-THRESHOLD ⁷Li(p,n)⁷Be NEUTRONS

Kenichi Tanaka, et al; Kyoto University, Japan

OR-18 FEASIBILITY STUDY ON THE USE OF PARAFFIN MODERATED FAST NEUTRON BEAMS FOR ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY

Dong Han Lee, et al; Korea Cancer Center Hospital, Korea

OR-19 IN-PHANTOM DOSIMETRY USING THE ¹³C(d,n)¹⁴N REACTION FOR BNCT

Alejandro Burlon, et al; Comision Nacional de Energнa Atуmica, Argentina #121,

OR-20 STUDY OF THE POTENTIAL OF USING ⁹Be(p,n) FOR BNCT CLINICAL

Nate Stone, et al; University of California Berkeley, U.S.A.

Biological Evaluation of BSH and BPA

October 3^rd 13:30～15:10 Conference Hall C (1002)

Chairman: Kazuo Yoshino, Sinshu University, Japan

Stephen Bruce Kahl, University of California, U.S.A.

OR-21 CELL CYCLE DEPENDENCE OF BORON UPTAKE IN VARIOUS BORON COMPOUNDS USED FOR NEUTRON CAPTURE THERAPY

Fumiyo Yoshida, et al; University of Tsukuba, Japan

OR-22 BPA & BSH ACCUMULATION IN EXPERIMENTAL TUMORS

Hemant Patel, et al; Beth Israel Deaconess Medical Center, U.S.A.

OR-23 IN VITRO AND IN VIVO ANALYSIS OF BORONATED PORPHYRINS

Benjamin Frank Edwards, et al; University of California Davis, U.S.A.

OR-24 MONITORING TOTAL BORON IN BLOOD FOR BNCT BY A NOVEL ATOMIC EMISSION METHOD

Juha Tapani Laakso, et al; University of Helsinki, Finland

OR-25 A CORE LABORATORY OFFERING FULL EVALUATION OF NEW BORON COMPOUNDS: A SERVICE TO THE BNCT COMMUNITY

Robert G. Zamenhof, et al; Beth Israel Deaconess Medical Center, U.S.A.

Localization of BSH, BPA and BOPP in the Cell

October 3^rd15:40～17:20 Conference Hall C (1002)

Chairman: Yoshinobu Fukumori, Kobe Gakuin University, Japan

Debra A. Feakes, SWT, U.S.A.

OR-26 THE CHEMICAL STATE OF BSH FOLLOWING ADMINISTRATION TO PATIENTS WITH GLIOBLASTOMA MULTIFORME

Benjamin Gilbert, et al; UW-Madison, U.S.A.

OR-27 THE INTERACTION OF Na₂B₁₂H₁₁SH(BSH) WITH LIPOSOMES; RELEVANCE TO CELLULAR BSH UPTAKE

Detlef Gabel, et al; University of Bremen, Germany

OR-28 CELLULAR AND SUBCELLULAR DISTRIBUTION OF BSH IN HUMAN GLIOBLASTOMA MULTIFORME

Michael Neumann, et al; University of Bremen, Germany

OR-29 PHARMACOLOGY STUDIES OF Na₂¹⁰B₁₀H₁₀ (GB-10) IN TUMOR PATIENTS

Richard J. Wiersema, et al; Neutron Therapies, U.S.A.

OR-30 PHASE I AND PHARMACOKINETIC STUDY OF BOPP IN HIGH GRADE GLIOMA PATIENTS

Stephen Bruce Kahl, et al; University of California, U.S.A.

Measurement

October 4^th 9:00～10:20 Conference Hall A (1003)

Chairman : David W. Nigg, INEEL, U.S.A.

Yoshinori Hayakawa, University of Toin, Japan

OR-31 PROMPT GAMMA RAY MEASUREMENT IN THE KUR IRRADIATION ROOM BY Cd-Zn-Te SEMICONDUCTOR DETECTOR FOR PG-SPECT

Tooru Kobayashi, et al; Kyoto University, Japan

OR-32 TOWARDS CLINICAL APPLICATION OF PROMPT GAMMA SPECTROSCOPY FOR IN-VIVO MONITORING OF BORON UPTAKE IN BNCT

Per Martin Munck af Rosenschцld, et al; Lund University Hospital, Sweden

OR-33 MICRODOSIMETRY FOR NEUTRON CAPTURE THERAPY USING RECOMBINATION CHAMBER

Mieczyslaw Leon Zielcynski, et al; Institute of Atomic Energy, Poland

OR-34 MEASUREMENTS OF LINEAL ENERGY SPECTRA FOR THE BNCT TEST BEAM OF THOR

Chuan-Jong Tung, et al; National Tsing Hua University, R.O.C.

Emerging Applications of NCT

October 4^th 9:00～10:20 Conference Hall B (1001)

Chairman: Junichi Hiratsuka, Kawasaki Medical School, Japan 　　　

Paul Martin Busse, Harvard Medical School, U.S.A

OR-35 THE EFFECTS OF BORON NEUTRON CAPTURE THERAPY ON LIVER TUMORS AND NORMAL HEPATOCYTES IN MICE

Minoru Suzuki, et al; Kinki University, Japan

OR-36 BIODISTRIBUTION OF BPA IN A THYROID UNDIFFERENTIATED CARCINOMA MODEL

Mario Alberto Pisarev, et al; Argentine Atomic Energy Commission, Argentina

OR-37 IN VIVO TYROSINASE MINI-GENE TRANSFER ENHANCES KILLING EFFECT OF BNCT ON AMELANOTIC MELANOMA

Hirofumi Kondoh, et al; Mishima Inst. for Dermatol. Res., Japan

OR-38 BORON NEUTRON CAPTURE SYNOVECTOMY AT SINQ IN SWITZERLAND

Nigel E. A. Crompton, et al; Paul Scherrer Institute, Switzerland

Fast Neutron Therapy and NCT

October 4^th 9:00～10:20 Conference Hall C (1003)

Chairman: C-K Chris Wang, Georgia Institute of Technology, U.S.A.

　　　 Shin-ichiro Masunaga, Kyoto University, Japan

OR-39 ¹⁰Ｂ-AUGMENTED FAST NEUTRON RADIOSURGERY FOR BRAIN TUMOR TREATMENT

C-K Chris Wang, et al; Georgia Institute of Technology, U.S.A.

OR-40 BNCT ENHANCED FAST NEUTRON THERAPY; in-vivo STUDIES FOR PREPARING A CLINICAL TRAIAL AT THE ESSEN CYCLOTRON

Andrea Wittig, et al; University of Essen, Germany

OR-41 DEVELOPMENT OF MINIATURE HIGH-DOSE-RATE ²⁵²Cf SOURCES FOR BORON-ENHANCED AND FAST NEUTRON BRACHYTHERAPY

Rodger C. Martin, et al; Oak Ridge National Laboratory, U.S.A.

OR-42 MEDICAL ASPECTS OF EXTERNAL BEAM NEUTRON AND NEUTRON-CAPTURE THERAPY OF MALIGNANT TUMORS

Aleksey S. Sysoev, et al; Mrrc, Russia

October 5^th 10:30～12:10 Conference Hall A (1003)

Chairmen: Renй Huiskamp, NRG, The Netherlands

Koichi Ando, Natl. Inst. Radiol. Sci., Japan

Drug Delivery Trials

OR-43 TUMOR GROWTH SUPPRESSION BY BORON NEUTRON CAPTURE THERAPY USING PEG-LIPOSOMAL BORON DELIVERY IN VIVO

Hironobu Yanagiл, et al; University of Tokyo, Japan

OR-44 BNCT OF INTRACEREBRAL MELANOMA: ENHANCED SURVIVAL AND CURE FOLLOWING CEREPORT^TM MEDIATED OPENING OF THE BLOOD-BRAIN BARRIER

Rolf F. Barth, et al; The Ohio State University, U.S.A.

OR-45 ENHANCED SURVIVAL OF GLIOMA BEARING RATS USING A COMBINATION OF BORONATED EPIDERMAL GROWTH FACTOR AND BORONOPHENYLALANINE

Weilian Yang, et al; The Ohio State University, U.S.A.

OR-46 PREPARATION OF A RADIOACTIVE BORON COMPOUND (B-I-131-LIPIODOL) FOR NEUTRON CAPTURE THERAPY OF HEPATOMA

Fong-In Chou, et al; National Tsing Hua University, R.O.C.

OR-47 APPLICATION OF ¹⁰BSH ENTRAPPED TRANSFERRIN-PEG-LIPOSOME TO BORON NEUTRON-CAPTURE THERAPY (BNCT) FOR SOLID TUMOR

Kazuo Maruyama, et al; Teikyo University, Japan

Dosimetry

October 5^th 10:30～12:10 Conference Hall B (1001)

Chairman : Robert G. Zamenhoff, Beth Israel Hospital, U.S.A.

Yoshihiko Onizuka, Kyushu University, Japan

OR-48 IMAGING AND PROFILING OF ABSORBED DOSE IN A TISSUE-EQUIVALENT GEL-PHANTOM EXPOSED TO EPITHERMAL NEUTRONS

Grazia Gambarini, et al; Dip. Fisica University, Italy

OR-49 EFFECTIVE ENERGY AND TRANSMITTANCE OF LIGHT WATER FOR SPECTRUM MODULATED OUTPUT BEAMS OF THE JRR4 BNCT EXPOSURE FACILITY

Hisao Kobayashi, et al; Rikkyo University, Japan

OR-50 USAGE OF A SINGLE TLD-700 FOR GAMMA DOSE MEASUREMENT IN A WATER PHANTOM IRRADIATED WITH THE EPITHERMAL NEUTRON BEAM AT THE THOR RESEARCH REACTOR

Hong-Ming Liu, et al; National Tsing Hua University, R.O.C.

OR-51 IN VIVO DOSIMETRY FOR BNCT

Johanna Maria Karila, et al; University of Helsinki, Finland

OR-52 DOSE PROFILING BY MEANS OF TL DOSIMETERS, IN PHANTOMS EXPOSED IN NEUTRON FIELDS: SEPARATION OF VARIOUS DOSE CONTRIBUTIONS

Giorgio G. Curzio, et al; Pisa University, Italy

New Compounds and Their Biological Properties and Others

October 5^th 10:30～12:10 Conference Hall C (1002)

Chairman: Yoshio Imahori, Kyoto Prefect University of Medicine, Japan

Merja E. Kallio, Huch Clin. Res. Inst., Finland

OR-53 NEW CARBON-CARBON LINKED AMPHIPHILIC CARBORANYL-PORPHYRINS AS BORON NEUTRON CAPTURE AGENTS

Maria. G.H. Vicente, et al; University of California Davis, U.S.A.

OR-54 ALPHA-AMINO ALCOHOL OF PARA-BORONOPHENYLALANINE, BPAoI, AS A POTENTIAL BORON CARRIER FOR BNCT

Masao Takagaki, et al; Research Reactor Institute of Kyoto University, Japan

OR-55 SYNTHESIS AND IN VIVO EVALUATION OF CARBORANE GADOLINIUM-DTPA COMPLEX AS AN MR IMAGING BORON CARRIER

Yoshinori Yamamoto, et al; Tohoku University, Japan

OR-56 THE DEVELOPMENT AND PRELIMINARY TESTING OF NEW BORONATED AGENTS FOR BNCT BASED ON PET DERIVED DATA

Trent Lee Nichols, et al; University of Tennessee, U.S.A.

OR-57 BIODISTRIBUTION AND PHARMACOKINETICS OF A CARBORANE-CONTAINING PORPHYRIN IN THE HAMSTER CHEEK POUCH (HCP) CARCINOGENESIS MODEL

Amanda Elena Schwint, et al; National Atomic Energy Commission, Argentina

Physics and Technology General

October 6^th 10:30～12:10 Conference Hall A (1003)

Chairman : Raymond Lloyd Moss, JRC/IAM Petten, The Netherlands

Kiyomitsu Kawachi, Nuclear Safety Technology Center, Japan

OR-58 QUALITY ASSURANCE FOR BNCT AT NUCLEAR FACILITIES -A NECESSARY BURDEN OR THE UNAVOIDABLE SEAL OF APPROVAL

Raymond Lloyd Moss, et al; JRC/IAM Petten, The Netherlands

OR-59 DEPTH-DOSE EVALUATION FOR LUNG AND PANCREAS CANCER TREATMENT BY BNCT USING AN EPITHERMAL NEUTRON BEAM

Tetsuo Matsumoto, et al; Musashi Institute of Technology, Japan

OR-60 USE OF POSITRON EMISSION TOMOGRAPHY FOR DETERMINATION OF TISSUE SPECIFIC KINETICS

Laurence F. Miller, et al; The University of Tennessee, U.S.A.

OR-61 APPLICATION OF THE NEW RADIATION TRANSPORT (TMG) TECHNIQUE IN DOSE CALCULATIONS

Petri M. Kotiluoto, et al; VTT Chemical Technology, Finland

OR-62 THE IMPACT OF NEW DECAY DATA FOR ¹⁸⁷W ON EPITHERMAL BEAM CHARACTERIZATION

Tom Ove Serйn, et al; VTT Chemical Technology, Finland
Boron Distribution, Dosimetry and Treatment Planning in Patients

October 6^th 10:30～12:10 Conference Hall B (1001)

Chairman: Hiroshi Fukuda, Tohoku University, Japan

Nilendu Gupta, The Ohio State University, U.S.A.

OR-63 DOSIMETRY IMPLICATIONS OF BSH BIODISTRIBUTION STUDY AT OSU

Nilendu Gupta, et al; The Ohio State University, U.S.A.

OR-64 TIME FACTOR OF BSH FROM INTRAVENOUS INFUSION TO NEUTORON IRRADIATION FOR BNCT IN PATIENTS WITH GLIOBLASTOMA

Teruyoshi Kageji, et al; The University of Tokushima, Japan

OR-65 PREDICTION OF BORON CONCENTRATION IN BLOOD FROM LOW DOSE INFUSION FOR THE PATIENTS OF BNCT AT JAERI

Yasushi Shibata, et al; University of Tsukuba, Japan

OR-66 TREATMENT PLANNING AND DOSIMETRY FOR THE HARVARD-MIT PHASE-Ⅰ CLINICAL TRIAL FOR CRANIAL BNCT

Matthew R. Palmer, et al; Harvard Medical School, U.S.A.

OR-67 THE USE OF POSITRON EMISSION TOMOGRAPHY IN BNCT TREATMENT PLANNING FOR METASTATIC MALIGNANT MELANOMA AND GLIOBLASTOMA MULTIFORME

George Walter Kabalka, et al; University of Tennessee, U.S.A.

Molecular Design and Synthesis of New Compounds

October 6^th 10:30～12:10 Conference Hall C (1002)

Chairman: Yoshinori Yamamoto, Tohoku University, Japan

Maria G.H. Vicente, University of California, Davis, U.S.A.

OR-68 AZABORANES　(RNH₂)B₈H₁₁NHR - A NEW TYPE OF BORON CLUSTER FOR POSSIBLE USE IN BNCT

Udo Dцrfler, et al; University of Bremen, Germany

OR-69 MEDICINAL UTILITY OF BORON CLUSTERS: RECEPTOR MODULATORS BEARING CARBORANE AS A HYDROPHOBIC PHARMACOPHORE

Yasuyuki Endo, et al; University of Tokyo, Japan

OR-70 PREPARATION AND EVALUATION OF UNILAMELLAR LIPOSOMES INCORPORATING BORON-CONTAINING DERIVATIVES OF CHOLESTEROL

Debra A. Feakes, et al; Southwest Texas State University, U.S.A.

OR-71 BORONATED NUCLEOSIDES FOR BNCT

Werner Tjarks, et al; The Ohio State University, U.S.A.

OR-72 SYNTHESIS AND EVALUATION OF BORONATED FOLATES FOR BNCT

Masaru Sekido, et al; The Ohio State University, U.S.A.

POSTER PRESENTATION

Clinical Results and Practice

PO-1 FOLLOW UP OF GLIOBLASTOMA PATIENTS TREATED WITH BNCT USING SPECTROSCOPIC IMAGING

Leena Marja Kankaanranta, et al; Helsinki University Central Hospital, Finland

PO-2 FOUR CASES OF FACIAL MELANOMA TREATED BY BNCT WITH ¹⁰B-p-BORONOPHENYLALANINE

Hiroshi Fukuda, et al; Tohoku University, Japan

PO-3　LONG TERM OUTCOME OF BORON NEUTRON CAPTURE THERAPY FOR MALIGNANT MELANOMA

Junichi Hiratsuka, et al; Kawasaki Medical School, Japan

PO-4 BORON NEUTRON CAPTURE THERAPY USING BORONOPHENYLALANINE FOR HIGH -GRADE GLIOMA IN JAPAN

Yoshio Imahori, et al; Kyoto Prefectural University of Medicine, Japan

PO-5 ANESTHETIC MANAGEMENT OF BORON NEUTRON CAPTURE THERAPY FOR GLIOBLASTOMA

Tetsutaro Shinomura, et al; Kyoto University, Japan

PO-6 OPTIMIZATION OF INTRAOPERATIVE (IO) BNCT: PRE-IRRADIATION SURGICAL TECHNIQUE AND 2-D DOSIMETRY IN SURGICAL FIELD

Susumu Yasuda, et al; University of Tsukuba, Japan
Dose and Planning in Patients

PO-7 CALCULATED DOSES AND DOSE DISTRIBUTIONS FOR GLIOBLASTOMA MULTIFORME PATIENTS TREATED WITH BORON NEUTRON CAPTURE THERAPY AT THE BROOKHAVEN MEDICAL RESEARCH REACTOR

Ruimei Ma, et al; Brookhaven National Laboratory, U.S.A.

PO-8 BNCT_RTPE AND SERA DOSE PLANNING PROGRAMS: PHANTOM AND PATIENT STUDIES

Tiina K. Seppдlд, et al; University of Helsinki, Finland

PO-9 PATIENT POSITIONING AND ITS INFLUENCE ON DOSE DISTRIBUTION

James Morrissey, et al; JRC Petten, The Netherlands

PO-10 FACTORS INTERFERING WITH COMPARISON OF RADIATION DOSES TO GBM PATIENTS TREATED WITH BORON NEUTRON CAPTURE THERAPY AT PETTEN AND BROOKHAVEN

Renй Huiskamp, et al; NRG, The Netherlands

PO-11 REFERENCE DOSIMETRY CALCULATIONS FOR NCT WITH COMPARISON OF ANALYTICAL AND VOXEL MODELS

Tim Goorley, et al; MIT, U.S.A.

PO-12 MODELING AND OPTIMIZATION OF TISSUE ¹⁰B CONCENTRATION AND DOSIMETRY FOR ARBITRARY BPA-F INFUSION SCHEDULES IN HUMANS

Thomas H. Newton, et al; MIT, U.S.A.

PO-13 A NOVEL TREATMENT PLANNING SCHEME FOR ¹⁰Ｂ-ENHANCED ²⁵²CF BRACHYTHERAPY

David S. Halpern, et al; Isotron Inc., U.S.A.
New Project and Others

PO-14 RECENT BNCT ACTIVITY PERFORMED BY PISA CALCULATION GROUP

Nicola Cerullo, et al; Genova University, Italy

PO-15 LICENSE REQUIREMENTS FOR THE MITR FISSION CONVERTER

John A. Bernard, et al; MIT, U.S.A.

PO-16 THE STUDSVIK BNCT PROJECT: STRUCTURE AND THE PROPOSED PROTOCOLS

Jacek Capala, et al; Studsvik Medical AB, Sweden

PO-17 THE BNCT PROJECT IN THE CZECH REPUBLIC

Jiri Burian, et al; Nucl. Res. Inst., Czech Republic

PO-18 QUALITY CONTROL PROCEDURE OF THE BNCT PATIENT DOSE DETERMINATION

Hanna Katariina Bjugg, et al; University of Helsinki, Finland

PO-19 IMPROVEMENT OF B-10 DOSE DISTRIBUTION IN WATER PHANTOM IRRADIATED WITH EPITHERMAL NEUTRON BEAM AND ITS ASSESSMENT BY COLO NY FORMATION ASSAY

Koji Ono, et al; Kyoto University, Japan

PO-20 MEDICAL SETUP OF INTRAOPERATIVE BNCT AT JRR-4

Hiroyoshi Akutsu, et al; University of Tsukuba, Japan

PO-21 GENE TRANSFER-APPLIED BNCT (g-BNCT) FOR AMELANOTIC MELANOMA IN BRAIN -FURTHER UPREGULATION OF ¹⁰B UPTAKE BY CELL MODULATION-

Masaki Iwakura, et al; Kobe University, Japan
Biology (In Vitro Study)

PO-22 ROTATING IRRADIATION SYSTEM FOR IN VITRO BNCT EXPERIMENTS AT JRR-4

Akira Matsushita, et al; University of Tsukuba, Japan

PO-23 RADIOBIOLOGICAL CHARACTERIZATION OF EPITHERMAL AND MIXED THERMAL-EPITHERMAL BEAMS AT JRR-4

Tetsuya Yamamoto, et al; University of Tsukuba, Japan

PO-24 BIOLOGICAL EFFECTS OF EPITHERMAL NEUTRONS

Hiroshi Utsumi, et al; Kyoto University, Japan

PO-25 GENOTOXIC EFFECTS OF BORON NEUTRON CAPTURE REACTION IN HUMAN MELANOMA CELLS

Nuno Guerreiro Oliveira, et al; Fac. Pharmacy Lisbon, Portugal

PO-26 RADIOBIOLOGY OF BNCT WITH COLD NEUTRONS IN DIFFERENT GEOMETRIES

Katharina H.I. Philipp, et al; GKSS Research Center Geesthacht, Germany

PO-27 LET DEPENDENCE OF HEAVY-ION BEAMS ON CELL KILLING UPON DNA-DSB REPAIR GENE KNOCKOUT STRAINS

Yoshiya Furusawa, et al; Natl. Inst. Radiol. Sci., Japan

PO-28 A STUDY OF THE INDUCTION OF CHROMOSOMAL ABERATIONS IN HUMAN BREAST CANCER CELLS WITH CALIFORNIUM-252

Thomas Edward Byrne, et al; Roane State, U.S.A.

PO-29 MUTAGENIC EFFECT OF BORONOPHENYLALANINE AND BOROCAPTATE IN NEUTRON CAPTURE THERAPY

Yuko Kinashi, et al; Kyoto University, Japan

PO-30 GLIOBLASTOMA, GADOLINIUM(Ⅲ) AND NCT: AN IN VITRO STUDY

Delio Mercanti, et al; CNR, Italy
Biology (In Vivo Study)

PO-31 RBE OF THE NCT BEAM AT PETTEN (THE NETHERLANDS) FOR INTESTINAL CRYPT REGENERATION IN MICE

John Gueulette, et al; Universitй Catholique de Louvain, Belgium

PO-32 THE PROLIFERATIVE RESPONSE OF MOUSE INTESTINAL CRYPTS DURING FRACTIONATED IRRADIATION OF CARBON BEAMS

Mitsuru Abo, et al; Hirosaki University, Japan

PO-33 NEW PERSPECTIVE FOR GdNCT: Gd-DTPA REACHES THE NUCLEUS OF GLIOBLASTOMA CELLS IN CULTURE AND IN VIVO

Gelsomina De Stasio, et al; University of Wisconsin, U.S.A.

PO-34 TOWARDS GADOLINIUM NEUTRON CAPTURE THERAPY

Finn Stecher-Rasmussen, et al; NRG-Petten, The Netherlands

PO-35 I INTRATUMOR HETEROGENEOUS DISTRIBUTION OF ¹⁰Ｂ-COMPOUNDS SUGGESTED BY THE RADIOBIOLOGICAL FINDINGS FROM IN VIVO MOUSE STUDIES

Shin-ichiro Masunaga, et al; Kyoto University, Japan
Reactor Neutron Source

PO-36 THE RESEARCH OF THE CHARACTERISTICS OF FIELDS OF FAST NEUTRONS ON A BEAM B-3 OF REACTOR BR-10 AND THE RESULTS OF NEUTRON THERAPY ON THE AFFECTED BY CANCER TUMORS

V. M. Lityaev, et al; A.I. Leipunsky Institute of Physics and Power Engineering, Russia

PO-37 COLLIMATOR OPTIMIZATION STUDIES FOR THE NEW MIT EPITHERMAL NEUTRON BEAM

Kent J. Riley, et al; MIT, U.S.A.

PO-38 SHIELDING AND BEAM PERFORMANCE OF THE NEW EPITHERMAL NEUTRON IRRADIATION FACILITY AT THE MITR-Ⅱ

Peter J. Binns, et al; MIT, U.S.A.

PO-39 AUTOMATIC CONTROL AND MONITORING OF THE MIT FISSION CONVERTER BEAM

Benjamin Allen Wilson, et al; MIT, U.S.A.

PO-40 A DESIGN STUDY ON HYPER-THERMAL NEUTRON IRRADIATION FIELD FOR NEUTRON CAPTURE THERAPY AT KYOTO UNIVERSITY REACTOR　

Yoshinori Sakurai, et al; Kyoto University, Japan

PO-41 THE BNCT IRRADIATION FACILITY OF JRR-4

Yoshiya Torii, et al; Japan Atomic Energy Research Institute, Japan

PO-42 CHARACTERISTICS OF NEUTRON BEAMS AT JRR-4 FOR BNCT

Kazuyoshi Yamamoto, et al; Japan Atomic Energy Research Institute, Japan

PO-43 DESIGN CALCULATIONS OF AN EPITHERMAL NEUTRON BEAM AND DEVELOPMENT OF A TREATMENT PLANNING SYSTEM FOR THE RENOVATION OF THOR FOR BORON NEUTRON CAPTURE THERAPY

Yen-Wan Hsueh Liu, et al; National Tsing Hua University, R.O.C.

PO-44 CONSTRUCTION OF NCT IRRADIATION ROOM AT HANARO

Byung Chul Lee, et al; Korea Atomic Energy Research Institute, Korea
Accelerator Neutron Source

PO-45 ACCELERATOR BASED NEUTRON SOURCE FOR THE NEUTRON CAPTURE THERAPY AT HOSPITAL

Sergey Yu. Taskaev, et al; Budker Inst. Nucl. Phys., Russia

PO-46 HIGH-CURRENT ELECTROSTATIC ACCELERATOR-TANDEM FOR THE NEUTRON THERAPY FACILITY

Grigorii I. Silvestrov, et al; Budker Inst. Nucl. Phys., Russia

PO-47 NEUTRON PRODUCING TARGET FOR NEUTRON CAPTURE THERAPY

Victor N. Kononov, et al; Inst. Phys. and Power Engineering, Russia

PO-48 COMPARATIVE ANALYSIS OF ABILITIES OF REACTOR BEAMS AND ACCELERATOR BASED NEUTRON SOURCE FOR BNCT AND FAST NEUTRON THERAPY

Valery V. Korobeinikov, et al; Institute of Physics and Power Engineering, Russia

PO-49 ACCELERATION OF NEUTRON BEAM BY PARTICLE COLLISION WITH LOW ENERGY PROTONS IN STORAGE SYSTEM

Yoshinori Hayakawa, Toin University of Yokohama, Japan

PO-50 DEVELOPMENT OF A COMPACT NEUTRON TUBE FOR BNCT APPLICATION

Ka-Ngo Leung, et al; Lawrence Berkely National Laboratory, U.S.A.
Measurement

PO-51 OPTIMIZATION OF DETECTOR SIZE AND COLLIMATOR FOR PG-SPECT

Masayori Ishikawa, et al; Hiroshima University, Japan

PO-52 THE BORON CONCENTRATION MEASUREMENT BY THE PROMPT GAMMA-RAY ANALYSIS DEVICE AT JRR-4

Naohiko Hori, et al; Japan Atomic Energy Research Institute, Japan

PO-53 MICRODOSIMETRY OF EPITHERMAL NEUTRON BEAM

Yoshihiko Onizuka, et al; Kyushu University, Japan

PO-54 IN PHANTOM DOSIMETRY IMPROVEMENT AT THE RA-6 BEAM

Juan Manuel Longhino, et al; Centro Atуmico Bariloche, Argentina

PO-55 IN-VIVO MEASUREMENTS WITH TLD DETECTORS FOR BNCT OF GLIOBLASTOMA PATIENTS AT THE HIGH-FLUX RESEARCH REACTOR PETTEN/NL

Elvira Finke, et al; Universitдtsklinikum Essen, Germany
Dosimetry

PO-56 2-D THERMAL NEUTRON DISTRIBUTION FOR INTRAOPERATIVE BORON NEUTRON CAPTURE THERAPY (IOBNCT)

Kei Nakai, et al; University of Tsukuba, Japan

PO-57 HIGH RESOLUTION ALPHA-AUTORADIOGRAPHY FOR MEASUREMENT OF ¹⁰Ｂ DISTRIBUTION IN SUBCELLULAR SCALE USING CR-39 AND AFM

Kuniaki Amemiya, et al; University of Tokyo, Japan

PO-58 IN VIVO MEASUREMENT OF ABSORBED DOSE OF THE NEUTRON-INDUCED PARTICLES IN THE ¹⁰B-CONTAINING TUMOR OF MOUSE

Koichi Ogura, et al; Nihon University, Japan

PO-59 A NEW PROBABILISTIC APPROACH TO THE MICRODOSIMETRY OF BNCT

Gustavo Alberto Santa Cruz, et al; Harvard Medical School, U.S.A.

PO-60 PRELIMINARY STUDY ON 2-DIMENTIONAL DISTRIBUTIONS OF ¹⁰B REACTION RATE IN A WATER PHANTOM WITH BORON- DOPED CR-39 FOR ⁷Li(p,n)⁷Be NEUTRONS BY 1.95 MeV PROTONS

Yukinori Hasegawa, et al; Kyoto University, Japan
Physics and Technology General

PO-61 DEVELOPMENT OF THE PATIENT SETTING SYSTEM FOR BNCT AT JRR-4

Hiroaki Kumada, et al; Japan Atomic Energy Research Institute, Japan

PO-62 POSITION DISPLACEMENT EFFECT ON THE DOSES IN THE PERIPHERAL HEAD REGIONS

Mika Karel Kortesniemi, et al; Helsinki University, Finland

PO-63 TREATMENT PLANNING SOURCE ASSESMENT

Osvaldo Calzetta Larrieu, et al; Centro Atуmico Bariloche, Argentina
BSH and Related Compounds

PO-64 BORON-RICH OLIGOMERS FOR BNCT

Marc Gula, et al; University of Bremen, Germany

PO-65 UPTAKE OF BSH IN M2R MELANOMA CELLS MONITORED BY NMR SPECTROSCOPY

Peter Bendel, et al; The Weizmann Institute of Science, Israel

PO-66 BNCT OF BRAIN TUMORS: BIODISTRIBUTION, PHARMACOKINETICS, AND RADIATION DOSIMETRY OF SODIUM BOROCAPTATE IN GLIOMA PATIENTS

Joseph H. Goodman, et al; The Ohio State University, U.S.A.

PO-67 STABILITY OF SODIUM MERCAPTODODECABORATE [BSH, Na₂B₁₂H₁₁SH]　IN WATER SOLUTION

Otomar Krнћ , et al; Katchem LTD., Czech Republic
BPA and Related Compounds

PO-68 DETERMINATION OF p-BORONOPHENYLALANINE-FRUCTOSE COMPLEX WITH PPM BORON CONCENTRATION USING ¹¹B-NMR

Takeshi Kameda, et al; Shinshu University, Japan

PO-69 COMPLEX FORMATION OF p-CARBOXYBENZENEBORONIC ACID WITH FRUCTOSE

T.M. Bulbul Islam, et al; Shinshu University, Japan

PO-70 ¹¹B-NMR SPECTROSCOPIC STUDY ON THE INTERACTION OF EPINEPHRINE AND p-BPA

Kazunori Ichihara, et al; Shinshu University, Japan

PO-71 INTERACTION BETWEEN p-BPA AND PRECURSOR OF MELANIN PREPARED FROM GREENE'S HAMSTER MELANOMA

Mamiko Takase, et al; Shinshu University, Japan

PO-72 MEASUREMENT OF OPTICAL PURITY OF p-BPA-TYROSINE DIPEPTIDE

Naoki Sato, et al; Shinshu University, Japan

PO-73 THE HAMSTER CHEEK POUCH (HCP) AS AN EXPERIMENTAL MODEL OF ORAL CANCER FOR BNCT: BIODISTRIBUTION AND PHARMACOKINETICS OF BPA

Erica Lorena Kreimann, et al; National Atomic Energy Commission, Argentina
New Boron Compounds

PO-74 CHLORIN DERIVATIVES FOR POTENTIAL USE IN BNCT

Jens Osterloh, et al; University of Bremen, Germany

PO-75 SYNTHESIS OF BORON-CONTAINING DIAMINES-AGENTS FOR BORON NEUTRON CAPTURE THERAPY

Mohamed E. EL-Zaria, et al; University of Bremen, Germany

PO-76 AZABORANES WITH HYDROXYPROPYL RESIDUES AS POSSIBLE NEW COMPOUNDS FOR USE IN BNCT

Claudia Bauer, et al; University of Bremen, Germany

PO-77 SYNTHESIS OF DOPAMINE ANALOGUE CONTAINING BENZENEBORONIC ACID GROUP, A TARGET COMPOUND FOR BNCT

Tadahiro Mizuno, et al; Shinshu University, Japan

PO-78 SYNTHESIS AND BIOLOGICAL EVALUATION OF BOTH ENANTIOMERS OF p-BORONOPHENYLALANINOL

Mitsunori Kirihata, et al; Osaka Prefecture University, Japan

PO-79 SYNTHESIS AND CYTOTOXICITY OF BORONATED FATTY ESTERS FOR BNCT OF CERVIX CANCER

Chinda Tambunchong, et al; Srinakharinwirot University, Thailand

PO-80 NEW BORAZINE COMPOUNDS FOR NEUTRON CAPTURE THERAPY

Hiroshi Yamashita, et al; National Institute of Materials and Chemical Research, Japan
Gadlinium-Containing Compounds, and Others

PO-81 ENHANCED CELLULAR ACCUMULATION OF GADOLINIUM INCORPORATED INTO CHITOSAN NANOPARTICLES

Futoshi Shikata, et al; Kobe Gakuin University, Japan

PO-82 BIODISTRIBUTION OF I.V. INJECTED GADOLINIUM-CONTAINING LIPID-NANOEMULSION IN TUMOR-BEARING HAMSTERS

Tetsuya Watanabe, et al; Kobe Gakuin University, Japan

PO-83 COMPARISON OF TWO BRAIN TUMOR-LOCALIZING MRI AGENT: GD-BOPTA AND GD-DTPA MRI AND ICP STUDY OF RAT BRAIN TUMOR MODEL

Tian Zhang, et al; Tsukuba University, Japan

PO-84 NON-INVASIVE IMAGING OF HUMAN TELOMERASE ACTIVITY - TARGETING ENZYME IN BNCT

Hitoshi Tujino, et al; Kyoto Prefectual University of Medicine, Japan

PO-85 POTENTIAL REAL-TIME MONITOR FOR BORON CONCENTRATION BASED UPON IR ABSORPTION SPECTROSCOPY

William F. Bauer, et al; INEEL, U.S.A.

PO-86 DETERMINATION OF BORON CONCENTRATION IN BIOPSY-SIZED TISSUE SAMPLES

Yongjin Hou, et al; University of California Davis, U.S.A.

PO-87 INTERACTION BETWEEN p-DIHYDROXYBORYLPHENYLALANINE AND ADRENALINE STUDIED BY A ZONE ELECTROPHORESIS

Yoshinori Kitaoka, et al; Kyoto University, Japan